This essay is an attempt to point up the gap between, on the one hand, the methods currently available to the biologist in the laboratory and, on the other, the kind of data that he or she would need in order to characterise genetically engineered proteins of topical biological interest in such a way as to make use of the techniques of protein engineering.

Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...) study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude and latency, and the end, but not the start, EP magnitude has a significant relationship to ongoing high gamma power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs. (shrink)

Physics depends on “physical intuition”, much of which is formulated in terms of Mathematics. Mathematics itself depends on Logic. The paper presents three latest novelties in Logic which have major consequences in Mathematics. Further, it presents two possible significant departures in Mathematics itself. These five departures can have major implications in Physics. Some of them are indicated, among them in Quantum Mechanics and Relativity.

It is often assumed that engaging in a one‐on‐one dialogue with a tutor is more effective than listening to a lecture or reading a text. Although earlier experiments have not always supported this hypothesis, this may be due in part to allowing the tutors to cover different content than the noninteractive instruction. In 7 experiments, we tested the interaction hypothesis under the constraint that (a) all students covered the same content during instruction, (b) the task domain was qualitative physics, (c) (...) the instruction was in natural language as opposed to mathematical or other formal languages, and (d) the instruction conformed with a widely observed pattern in human tutoring: Graesser, Person, and Magliano's 5‐step frame. In the experiments, we compared 2 kinds of human tutoring (spoken and computer mediated) with 2 kinds of natural‐language‐based computer tutoring (Why2‐Atlas and Why2‐AutoTutor) and 3 control conditions that involved studying texts. The results depended on whether the students' preparation matched the content of the instruction. When novices (students who had not taken college physics) studied content that was written for intermediates (students who had taken college physics), then tutorial dialogue was reliably more beneficial than less interactive instruction, with large effect sizes. When novices studied material written for novices or intermediates studied material written for intermediates, then tutorial dialogue was not reliably more effective than the text‐based control conditions. (shrink)

We examine three critical aspects of Popper’s formulation of the ‘ Logic of Scientific Discovery ’—evidence, content and degree of corroboration—and place these concepts in the context of the Tree of Life (ToL) problem with particular reference to molecular systematics. Content, in the sense discussed by Popper, refers to the breadth and scope of existence that a hypothesis purports to explain. Content, in conjunction with the amount of available and relevant evidence, determines the testability, or potential degree of corroboration, of (...) a statement; content distinguishes scientific hypotheses from metaphysical assertions. Degree of corroboration refers to the relative and tentative confidence assigned to one hypothesis over another, based upon the performance of each under critical tests. Here we suggest that systematists attempt to maximize content and evidence to increase the potential degree of corroboration in all phylogenetic endeavors. Discussion of this “total evidence” approach leads to several interesting conclusions about generating ToL hypotheses. (shrink)

Ogni tentativo di ripensare le nostre categorie politiche deve muovere dalla consapevolezza che della distinzione classica fra zoé e bios, tra vita naturale ed esistenza politica (o tra l'uomo come semplice vivente e l'uomo come soggetto politico), non ne sappiamo piú nulla. Nel diritto romano arcaico homo sacer era un uomo che chiunque poteva uccidere senza commettere omicidio e che non doveva però essere messo a morte nelle forme prescritte dal rito. È la vita uccidibile e insacrificabile dell' 'uomo sacro' (...) a fornire qui la chiave per una rilettura critica della nostra tradizione politica. Quando la vita diventa la posta in gioco della politica e questa si trasforma in biopolitica, tutte le categorie fondamentali della nostra riflessione, dai diritti dell'uomo alla democrazia alla cittadinanza, entrano in un processo di svuotamento e di dislocazione il cui risultato sta oggi davanti ai nostri occhi. Seguendo il filo del rapporto costitutivo fra nuda vita e potere sovrano, da Aristotele ad Auschwitz, dall'Habeas corpus alle Dichiarazioni dei diritti, il libro di Agamben cerca di decifrare gli enigmi - prima di tutti il fascismo e il nazismo - che il nostro secolo ha proposto alla ragione storica. Fino a vedere, nel campo di concentramento, il paradigma biopolitico nascosto della modernità in cui città e casa sono diventate indiscernibili e la possibilità di distinguere tra il nostro corpo biologico e il nostro corpo politico ci è stata tolta una volta per tutte. (shrink)

Die spekulative Frage, wie das Denken sich und somit ein Selbst denken kann, ist die prinzipientheoretische Grundfrage der Philosophie. In ihr ist auch die transzendentale Frage nach den Bedingungen der Möglichkeit des Denkens eines Gegenstandes überhaupt enthalten. Wie sie darin enthalten ist und inwiefern die transzendentale Fragestellung auf die spekulative verweist und ihrer bedarf, wird im Anschluß an Kant zu zeigen sein, denn die spekulative Frage ist nicht die Ausgangsfrage Kantens. Kant geht aus von der Antinomie von empiristischem Skeptizismus und (...) ontologischem Dogmatismus und spielt sie an der Differenz von Ding und Denken durch, die dieser Antinomie zugrundeliegt. Die Ontologie wird darum von ihm belehrt, daß sie das Gedankending nicht mit dem Gegenstand der Erfahrung und das Denken nicht mit dem Erkennen verwechseln dürfe. Der Empirismus wird hingegen belehrt, daß die Gegen-stände der Erfahrung und ihre Zusammensetzungen kein Gegebenes, sondern ein vom Denken mit Bezug auf das Anschauungsmaterial Gemachtes sind. Die Differenz von Ding und Denken bleibt solcherart in Kants transzendentaler Frage nach den Bedingungen der Möglichkeit des Denkens eines Gegenstandes überhaupt aufbewahrt. Sie macht sich in Kants Antworten auf diese Frage aber auch geltend und bleibt als bloße Differenz von Verstandesspontaneität und rezeptiver Sinnlichkeit der blinde Fleck, um den seine Argumentationen kreisen. Die ersten vier Kapitel des vorliegenden Buches folgen diesem Kreisgang der Kantischen Beweisführung. Das Beweisziel: die transzendentallogische Entdeckung der Formen des Denkens eines Gegenstandes überhaupt, versuchen die Kapitel 5 und 6 einzulösen, indem - im Gegensatz zur ‚exoterischen‘ Lehre Kantens und zur nach-idealistischen Standardinterpretation des Kritizismus - die Vereinbarung von transzendentalem Idealismus und empirischem Realismus nicht in einem Apriori gesucht wird, das schlechterdings mit dem ‚Verstande‘ zu identifizieren wäre, sondern das gegenstandskonstitutive Verstandesapriori vielmehr aus ursprünglichen - die Differenz von Verstand und Sinnlichkeit allererst ermöglichenden - Weisen der Synthesis entwickelt wird. Diese genetische Grundlegung des Apriori ist anhand der Prinzipien der klassischen Logik und einer Analyse des Seinssinnes der Kopula “ist” als transzendentallogische Differenzierung der Urteilssynthesis durchzuführen und mit Bezug auf die Gegebenheitsweisen Raum und Zeit durch eine korrespondierende transzendental-phänomenologische Analyse zu vervollständigen. Da das genetische Apriori aber nicht unmittelbar, sondern nur vermittels der reflexiv-synthetischen Bewußtseinsstruktur auf die Kantischen Gegenstandskategorien bezogen werden kann, bleibt in Fortführung des Nachweises der Vollständigkeit der Kantischen Kategorientafel die spekulative Frage zu beantworten, wie Synthesis (Vermittlung) und damit das Denken selbst zu denken ist. Dieser Aufgabe und den damit untrennbar verbundenen Problemen der Verhältnisbestimmung von transzendentaler und formaler Logik, sowie von regulativer und konstitutiver Apriorität, sind die letzten vier Kapitel gewidmet, wobei in diesem Problemzusammenhang der Begriff der Transzendentalphilosophie in Auseinandersetzung mit einigen ihrer vor- und nach-kantischen Positionen noch näher zu klären sein wird. Wollte man das Ergebnis dieser Klärung vorweg zusammenfassen, dann ließe sich in Abwandlung eines oft zitierten Kantischen Satzes sagen, daß die transzendentale Logik seit Platon keinen Schritt rückwärts und mit Kant erst einen Schritt vorwärts hat tun dürfen und folglich schon von den ältesten Zeiten her nahezu vollendet sei. Vordergründig betrachtet, relativiert dieses Resultat den historischen Anspruch, den Kant an seine ‚Revolution der Denkungsart‘ geknüpft hat, es bekräftigt dafür jedoch um so mehr den systematischen Anspruch, den die Transzendentalphilosophie als Prinzipientheorie erheben und auch einlösen muß. (shrink)

Why has fiction been so successful over time? We make the case that fiction may have properties that enhance both individual and group-level fitness by (a) allowing risk-free simulation of important scenarios, (b) effectively transmitting solutions to common problems, and (c) enhancing group cohesion through shared consumption of fictive worlds.

Dieser Titel aus dem De Gruyter-Verlagsarchiv ist digitalisiert worden, um ihn der wissenschaftlichen Forschung zugänglich zu machen. Da der Titel erstmals im Nationalsozialismus publiziert wurde, ist er in besonderem Maße in seinem historischen Kontext zu betrachten. Mehr erfahren Sie.

In early German ecology, the key concept used to refer to a synecological unit was Biozönose. Taken together with the concept of the Biotop, it was also understood as an integrated higher-order unit of life, sometimes called a “Holozön”. These units were often perceived as having properties similar to those of individual organisms, and they informed the mainstream of German ecology until at least the late 1960s. Here I ask how “organismic” these concepts really were and what conceptual problems they (...) entailed. To do so, I focus on some almost forgotten dissident positions, especially those of Friedrich Simon Bodenheimer and Fritz Peus, which I contrast with the mainstream German ecology of the time. In a radical paper published in 1954 that postulated the “dissolution of the concepts of biocoenosis and biotope”, Peus in particular elicited a forceful response from many prominent German ecologists. An analysis of the ensuing debate, including especially a colloquium held in 1959 that was partly inspired by Peus’ paper, is helpful for sifting the various arguments proffered with respect to a quasi-organismic perception of the biocoenosis in German speaking ecology. Although German mainstream ecologists rejected the notion of the biocoenosis as a superorganism, ontological holism was quite common among them. Additionally, the mainstream concept of the biocoenosis was plagued by several methodological problems and much conceptual confusion, to which the “dissidents” rightly pointed. Some of these problems are still pertinent today, e.g. in connection with more modern concepts such as “ecosystem”. (shrink)

Past research has found that mere in‐group/out‐group categorizations are sufficient to elicit biases in face memory. The current research yields novel evidence that mere social categorization is also sufficient to modulate processes underlying face perception, even for faces for which we have strong perceptual expertise: same‐race (SR) faces. Using the composite face paradigm, we find that SR faces categorized as in‐group members (i.e., fellow university students) are processed more holistically than are SR faces categorized as out‐group members (i.e., students at (...) another university). Hence, holding perceptual expertise with faces constant, categorizing an SR target as an out‐group member debilitates the strong holistic processing typically observed for SR faces. (shrink)

In this paper, I provide new foundations for experientialism about perceptual knowledge, the view that all perceptual knowledge derives from experience. §1 introduces the basic template for experientialism about perceptual knowledge and considers how recent work on perceptual justification encourages giving special attention to less intuitive ways of filling in the template. §2 and §3 draw attention to ways of filling in the template that are more compelling, including versions from the history of epistemology that are still taken seriously elsewhere (...) (e.g., in philosophy of mind and cognitive science). §4 spotlights one neglected kind of approach—anti-Humean experientialism—and highlights some of its attractive features. §5 concludes by noting how anti-Humean experientialism dissolves an influential problem for experientialism that originates in Sellars (1956). (shrink)

In Group Agency, List and Pettit defend ‘non-redundant realism’ about group agency, a view on which facts about group agents are not ‘readily reducible’ to facts about individuals, and the dependence of group agents on individuals is so holistic that one cannot predict facts about group agents on the basis of facts about their members. This paper undermines L&P's case in three stages. §1 shows that L&P's core argument is invalid. L&P infer and from two facts: that group agents must (...) often believe what few members personally believe, and that a group agent's beliefs in certain propositions must often ‘depend on’ member attitudes to distinct propositions. I note that is ambiguous, and that the only true reading of it is irrelevant to the status of. I argue further that cannot support, since a group agent's belief in P may neatly constitutively depend on member attitudes to P that are weaker than personal belief. §2 makes this idea concrete with a plausible toy theory of group belief that implies it. While this kind of theory is popular in the literature on joint belief, L&P never discuss it – a striking fact, since it explains why is true. Having made these points, I turn to argue in §3 that is either false or uncontroversial.Send article to KindleTo send this article to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service.HOW TO BE A REDUNDANT REALISTVolume 9, Issue 3Kurt L. SylvanDOI: https://doi.org/10.1017/epi.2012.16Your Kindle email address Please provide your Kindle [email protected]@kindle.com Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Dropbox To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox. HOW TO BE A REDUNDANT REALISTVolume 9, Issue 3Kurt L. SylvanDOI: https://doi.org/10.1017/epi.2012.16Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Google Drive To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive. HOW TO BE A REDUNDANT REALISTVolume 9, Issue 3Kurt L. SylvanDOI: https://doi.org/10.1017/epi.2012.16Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Export citation Request permission. (shrink)

We argue for a novel view of suspending judgment properly--i.e., suspending judgment in an ex post justified way. In so doing we argue for a Kantian virtue-theoretic view of epistemic normativity and against teleological virtue-theoretic accounts.

Die berühmte Philosophin Hannah Arendt, deren Name heute in Deutschland Schulen, Straße, Institute und auch ICE-Züge tragen, wurde 1906 in Hannover als Kind einer jüdischen Familie geboren. Sie las Philosophie in Heidelberg bei Martin Heidegger, mit dem sie auch eine heimliche Liebesbeziehung verband. Nach der Flucht vor den Nazis 1933 über Frankreich in die USA wurde Arendt mit einem Schlag berühmt, als sie 1963 ihr Buch "Eichmann in Jerusalem" veröffentlichte. Sie machte sich über die Grundlagen politischen Handelns vor allem anhand (...) totalitärer Systeme Gedanken und hielt dabei stets betont Abstand zu allen Denkschulen der Linken oder Rechten.Diese Unabhängigkeit, die sie selbst gerne als "Denken ohne Geländer" umschrieb, ist laut Sontheimer eine der wichtigsten Ursachen für ein nach dem Ende des Kalten Krieges wieder stark gestiegenes Interesse an Arendts Texten. Anhand des Lebenslaufs der Philosophin zeichnet Sontheimer ihre Denkansätze nach. "Das Hohelied der Freundschaft" überschreibt er ein sehr eindrucksvolles Kapitel über die intensiven, zum Teil über viele Jahrzehnte über hunderte von Briefen gepflegten Beziehungen der Autorin zu Zeitgenossen wie dem jüdischen Gelehrten Gershom Scholem, ihrem deutschen Lehrer und Kollegen Karl Jaspers und der US-Schriftstellerin Mary McCarthy. Am 4.12.2005 jährte sich der Todestag von Hannah Arendt zum 30. Mal. (shrink)